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        һ㷺ĸ༼ӦáϵͳָƷȻЩ⸱ʵ帴ӵĶʵʾ

        磬ӵģͣٵĵΪҩ↑ĻѧģѧӦרעڼض/¼Ԥಡضҽ豸ǻŻ

        ݽ컼ߵ״̬ǰѡתΪ컼ߵŻ״̬[1]Ϊ P4 ҽģʽĹؼ֡predictiveԤԣpersonalizedԻpreventiveעԤparticipatory룩

        ҽеӦ

        ÿ෽涼Ƕһ޶ģĿǰΪͨߡĴƷԡʵʻߡ˵Чʺܵ͡Чҩƺ⵽豸ܾ/彫ΪһеԻҽƵҪɲ֡

        ܽҽƱIJͬӦá

        01

        Ϻƾ֧

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        ԲͬԴ¼ԲʵҽŴĻݽϹṩģͽģӿٴвĻߵĽ״ͳģƶϳȱʧIJ磬Ѫܳͼ嶯ѧĽܹʵķԱָļ[1]

        02

        ˼໤ɴ豸

        СʵĿɴ豸Ϊеṩʵʱݡͨ׷ʶΪ֪ԼչͳĻռ㹻˽⣬ǿԿڽ׶μ֢״ģͣҽûǰϻ. ⣬ڼ䣬ǽܹǷЧ

        ѾкܶԴǵ壬ҪǵķأҽƼ¼ʵҲԽҩݣͼݣҸ豸ɵݣأ롢ϰߡ[2]

        03

        ģ

        

        ݶ壬ǸԻġӵǰ״̬ѽǸݻߵҪƵġԻ߸Ԥɹʺͽͻ߷Ҫ彫ͨģٴѡ֮ǰԤṩ[3]ҽ豸ѡλá򡢳ߴ硭ȷСǶȡ״

        04

        ҽеŻ

        MedTech

        サ㡣һ棬ӵолضĻһ棬ӵв׽豸Ƶҽ豸ǿԽģ͹ض豸װضʱᷢʲô޷û˺½ٴоȺ纱߻ƻ[3]

        ŻҲdzãͨڲͬͲͬٸģ豸ܡ⣬3D ӡij֣ͨΪÿߴصʵҽ豸ĸԻ

        05

        ҩ↑ͼŻ

        ٴ

        ǿͨ㴦ǧҩ壬ԱΪضȷõһֻ֡ȻⲢҪͣѾڵҩϡǿԴһɾвͬ͵ʵɵֶУЩ߾֢ͬ״µDZҩԤɹĿԼѼĽһ㽫ٱҪٴ

        ģٴ齫ʾҪʱڹ۲Ḷ́ķգٴоҪǧ۲е[4]

        06

        ܾ

         2016 ŷᶼʼģģҽҩƷܹе֤Դ[4]رǣ֤ҽ豸нԼɱDZ FDA ѳŵ֤תΪһмֵļܹߡ

        ⣬һЩ˾ʾٴijɱܺܿᳬ룬⽫ҵתҿɿԴ֤ҽеҩƷİȫԺЧ[3]

        ļ

        ӦúĿĸͬģҲӦö졣

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        彫ַ׼ȷԤ⼲ĸԭԼάָֻ;[1]

        01

        ͳƽģ

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        ͳƽģдƶϹϵѧ籴Ҷ˹ƵԼ˹ѧϰͳģѭɷʹѧȡŻԻ־ϡˣijЩ£DZΪϻӡЩڻ߼⡢Ϻƾ֧֡

        02

        ѧģģ

        еģ˻ǵѧ֪ʶͻѧɵģⷽѧ嶯ѧȡѧѧ͹ѧеģѭ﷽ṩһϺǿʵٴݡʶƺԤʹڿ¡ˣDZΪ׺СЩģ⡢ҽ豸Żҩ↑ͼܾߡ

        03

        

        ҽѧͿɴ豸

        ҽѧͿɴ豸ĽҽƱķչشӰ졣ҽѧ񹤾ڲ׽ߵ״̬ʽṹѧǻеģ͵Ҫ֮һɴ豸ΪʵʱԽл߼ͽͳģ͵Ĺؼ

        δδʮԸ

        ҽƱ򴴽ļѾڡ˾ͻٵսǿʼԲӦضҽƱ⡣

        ҽƱҵȽ˫Ӧڿеಡѧǿѧ֪ʶ[1.5.6]͹ҵչżij죬ӦҲ֮

        սҪ˷ΪδҽƱҪɲ֡

        ο

        [1]Corral-Acero J, Margara F, Marciniak M, Rodero C, Loncaric F, Feng Y, et al. The Digital Twin to enable the vision of precision cardiology. Eur Heart J 2020

        [2]Schwartz SM, Wildenhaus K, Bucher A, Byrd B. Digital Twins and the Emerging Science of Self: Implications for Digital Health Experience Design and Small Data. Front Comput Sci 2020

        [3]Morrison TM, Pathmanathan P, Adwan M, Margerrison E. Advancing regulatory science with computational modeling for medical devices at the FDAs office of science and engineering laboratories. Front Med 2018

        [4]Pappalardo F, Russo G, Tshinanu FM, Viceconti M. In silico clinical trials: Concepts and early adoptions. Brief Bioinform 2019

        [5]Niederer SA, Lumens J, Trayanova NA. Computational models in cardiology. Nat Rev Cardiol 2019

        [6]Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP. Machine learning in cardiovascular medicine: Are we there yet? Heart 2018

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